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Itpatm1Skmi
Targeted Allele Detail
Nomenclature
Symbol: Itpatm1Skmi
Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase); targeted mutation 1, Kunihiko Sakumi
MGI ID: MGI:4942407
Gene: Itpa  Location: Chr2:130667610-130681614 bp, + strand  Genetic Position: Chr2, 63.24 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169285
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 2, 3, and 4. The absence of protein expression was confirmed by western blot analysis on brain and liver extract. (J:169285)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itpa Mutation:  17 strains or lines available
References
Original:  J:169285 Behmanesh M, et al., ITPase-deficient mice show growth retardation and die before weaning. Cell Death Differ. 2009 Oct;16(10):1315-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory