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Transgene Detail
Symbol: Tg(Kit*D814V)1Roer
Name: transgene insertion 1, Axel Roers
MGI ID: MGI:4942357
Synonyms: kitD814Vflox
Transgene: Tg(Kit*D814V)1Roer  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Tg(Kit*D814V)1Roer expresses 1 gene
Mutation detailsThis transgene consists of a modified mouse BAC clone RP23-274L11 which contains the entire Kit locus. The Kit locus in the BAC was modified by the insertion of a floxed stop cassette into intron 1 and the insertion of an A to T point mutation in exon 17 resulting in an aspartic acid to valine mutation at position 814. This mutation is homologous to the D816V mutation in humans. This line carries 5 - 6 copies of the transgene. (J:169611)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:169611 Gerbaulet A, et al., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 2011 Feb 10;117(6):2012-21
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory