About   Help   FAQ
Pink1tm1Hbu
Targeted Allele Detail
Nomenclature
Symbol: Pink1tm1Hbu
Name: PTEN induced putative kinase 1; targeted mutation 1, Hansruedi Bueler
MGI ID: MGI:4941901
Gene: Pink1  Location: Chr4:138313409-138326296 bp, - strand  Genetic Position: Chr4, 70.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169471
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site replaced exons 4 and 5. The absence of transcript expression was confirmed by RT-PCR. (J:169471)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pink1 Mutation:  9 strains or lines available
References
Original:  J:169471 Akundi RS, et al., Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One. 2011;6(1):e16038
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory