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Gnao1tm4.1Lbi
Targeted Allele Detail
Nomenclature
Symbol: Gnao1tm4.1Lbi
Name: guanine nucleotide binding protein, alpha O; targeted mutation 4.1, Lutz Birnbaumer
MGI ID: MGI:4941848
Synonyms: Galphao-
Gene: Gnao1  Location: Chr8:93810561-93969388 bp, + strand  Genetic Position: Chr8, 45.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169627
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exons 5 and 6. The predicted product lacks all motifs that bind to adenylyl cyclases, phospholipase C, and betagamma subunits. (J:169627)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:  4 strains or lines available
References
Original:  J:169627 Zhao A, et al., Galphao represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes. 2010 Oct;59(10):2522-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory