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Cdk5tm1.1Lht
Targeted Allele Detail
Nomenclature
Symbol: Cdk5tm1.1Lht
Name: cyclin-dependent kinase 5; targeted mutation 1.1, Li-Huei Tsai
MGI ID: MGI:4941828
Synonyms: Cdk5fl
Gene: Cdk5  Location: Chr5:24418241-24423530 bp, - strand  Genetic Position: Chr5, 11.73 cM, cytoband A3-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169741
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 1-5 of the targeted gene were flanked by loxP sites and a FRT-flanked neomycin cassette was placed immediately 3'. Flp-mediated recombination removed the neo cassette. (J:169741)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdk5 Mutation:  6 strains or lines available
References
Original:  J:169741 Samuels BA, et al., Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron. 2007 Dec 6;56(5):823-37
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory