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Tg(Defa2-Myd88)1Lvh
Transgene Detail
Nomenclature
Symbol: Tg(Defa2-Myd88)1Lvh
Name: transgene insertion 1, Lora Hooper
MGI ID: MGI:4941629
Synonyms: Cr2-FlagMyd88
Transgene: Tg(Defa2-Myd88)1Lvh  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Defa2-Myd88)1Lvh expresses 1 gene
 
Mutation detailsFLAG-tagged Myd88 was placed under the transcriptional control of nucleotides -6500 to +134 of the mouse Defa2 (defensin, alpha, 2; also known as cryptdin 2) gene. Human growth hormone (hGH, +3 to +2150) was placed immediately downstream to enhance transgenic expression, but is not transcribed. (J:169662)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:169662 Vaishnava S, et al., Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20858-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory