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Nlgn3tm3.1Sud
Targeted Allele Detail
Summary
Symbol: Nlgn3tm3.1Sud
Name: neuroligin 3; targeted mutation 3.1, Thomas C Sudhof
MGI ID: MGI:4940407
Synonyms: Neuroligin 3 R704C, NL3R704C
Gene: Nlgn3  Location: ChrX:100342785-100364956 bp, + strand  Genetic Position: ChrX, 43.95 cM
Alliance: Nlgn3tm3.1Sud page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184114
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsArginine 704 (exon 8) was mutated to encode cysteine (R704C) and an FRT-flanked neomycin cassette (with a single, un-used loxP site) was placed in intron 7. Flp-mediated recombination removed the neo cassette. (J:184114)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlgn3 Mutation:  35 strains or lines available
References
Original:  J:184114 Etherton MR, et al., An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J. 2011 Jul 20;30(14):2908-19
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory