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Rims2tm1.1Sud
Targeted Allele Detail
Nomenclature
Symbol: Rims2tm1.1Sud
Name: regulating synaptic membrane exocytosis 2; targeted mutation 1.1, Thomas C Sudhof
MGI ID: MGI:4939895
Synonyms: RIM2alphabetagammafloxed
Gene: Rims2  Location: Chr15:39198286-39684372 bp, + strand  Genetic Position: Chr15, 15.45 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168840
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 26 was replaced with an FRT-flanked neo cassette and a floxed ECFP-tetracysteine tagged exon 26. Flp-mediated recombination removed the neo cassette leaving the tagged exon 26 floxed. (J:168840)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rims2 Mutation:  180 strains or lines available
References
Original:  J:168840 Kaeser PS, et al., RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell. 2011 Jan 21;144(2):282-95
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory