Mycbp2^tm1.1Klsc
Targeted Allele Detail

Summary

• Symbol: Mycbp2^tm1.1Klsc
• Name: MYC binding protein 2, E3 ubiquitin protein ligase; targeted mutation 1.1, Klaus Scholich
• MGI ID: MGI:4939601
• Synonyms: MYCBP2^lox
• Gene: Mycbp2 Location: Chr14:103350847-103584250 bp, - strand Genetic Position: Chr14, 51.79 cM
• Alliance: Mycbp2^tm1.1Klsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 11 was floxed. An FRT-flanked neo cassette was removed by flp-mediated recombination. (J:168745)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycbp2 Mutation: 223 strains or lines available

References

• Original: J:168745 Holland S, et al., The Ubiquitin Ligase MYCBP2 Regulates Transient Receptor Potential Vanilloid Receptor 1 (TRPV1) Internalization through Inhibition of p38 MAPK Signaling. J Biol Chem. 2011 Feb 4;286(5):3671-80
• All: 2 reference(s)