Sting1^gt
Chemically induced Allele Detail

Summary

• Symbol: Sting1^gt
• Name: stimulator of interferon response cGAMP interactor 1; goldenticket
• MGI ID: MGI:4939597
• Synonyms: Goldenticket (Gt), Sting^Gt, Tmem173^I199N
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^gt page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion that results in the amino acid substitution of asparagine for isoleucine at position 199 (I199N). The absence of protein expression was confirmed by western blot analysis on macrophage extracts. (J:168746)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 49 strains or lines available

References

• Original: J:168746 Sauer JD, et al., The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun. 2011 Feb;79(2):688-94
• All: 157 reference(s)