Spic^tm1Kmm
Targeted Allele Detail

Summary

• Symbol: Spic^tm1Kmm
• Name: Spi-C transcription factor (Spi-1/PU.1 related); targeted mutation 1, Kenneth M Murphy
• MGI ID: MGI:4939280
• Synonyms: Spi-C^-
• Gene: Spic Location: Chr10:88511131-88518885 bp, - strand Genetic Position: Chr10, 44.14 cM, cytoband C
• Alliance: Spic^tm1Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143900
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace exons 2-5 encoding the Spi-C transcription factor (Spi-1/PU.1 related) gene (Spic) with a loxP-flanked neomycin resistance (neo) cassette. (J:143900)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spic Mutation: 22 strains or lines available

References

• Original: J:143900 Kohyama M, et al., Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature. 2009 Jan 15;457(7227):318-21
• All: 1 reference(s)