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Ces1ctm1.1Loc
Targeted Allele Detail
Nomenclature
Symbol: Ces1ctm1.1Loc
Name: carboxylesterase 1C; targeted mutation 1.1, Oksana Lockridge
MGI ID: MGI:4938302
Gene: Ces1c  Location: Chr8:93825643-93857911 bp, - strand  Genetic Position: Chr8, 44.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168821
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of exon 5, and a neomycin resistance (neo) cassette followed by a single loxP site downstream of exon 5. Cre-mediated recombination removed exon 5 and the neo cassette. This deletion is predicted to abolish protein function. The absence of carboxylesterase activity in the plasma was confirmed by enzymatic assay. (J:168821)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ces1c Mutation:  27 strains or lines available
References
Original:  J:168821 Lockridge O, Direct Data Submission 2011/02/25. MGI Direct Data Submission. 2011;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory