Akt2^tm1.2Mbb
Targeted Allele Detail

Summary

• Symbol: Akt2^tm1.2Mbb
• Name: thymoma viral proto-oncogene 2; targeted mutation 1.2, Morris J Birnbaum
• MGI ID: MGI:4889113
• Synonyms: Akt2^flox, Akt2^lox, Akt2^loxP
• Gene: Akt2 Location: Chr7:27290977-27340251 bp, + strand Genetic Position: Chr7, 15.94 cM, cytoband B1
• Alliance: Akt2^tm1.2Mbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155432
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked PGK-neomycin resistance cassette was inserted into intron 5, and loxP sites were inserted flanking exons 4 and 5. Flp-mediated recombination removed the neo cassette leaving exons 4 and 5 floxed. (J:155432)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akt2 Mutation: 51 strains or lines available

References

• Original: J:155432 Leavens KF, et al., Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab. 2009 Nov;10(5):405-18
• All: 28 reference(s)