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Akt2tm1.2Mbb
Targeted Allele Detail
Nomenclature
Symbol: Akt2tm1.2Mbb
Name: thymoma viral proto-oncogene 2; targeted mutation 1.2, Morris J Birnbaum
MGI ID: MGI:4889113
Synonyms: Akt2flox, Akt2lox, Akt2loxP
Gene: Akt2  Location: Chr7:27591552-27640826 bp, + strand  Genetic Position: Chr7, 15.94 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155432
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked PGK-neomycin resistance cassette was inserted into intron 5, and loxP sites were inserted flanking exons 4 and 5. Flp-mediated recombination removed the neo cassette leaving exons 4 and 5 floxed. (J:155432)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akt2 Mutation:  26 strains or lines available
References
Original:  J:155432 Leavens KF, et al., Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab. 2009 Nov;10(5):405-18
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory