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Targeted Allele Detail
Symbol: Gnao1tm3Lbi
Name: guanine nucleotide binding protein, alpha O; targeted mutation 3, Lutz Birnbaumer
MGI ID: MGI:4889047
Synonyms: Go2alpha-
Gene: Gnao1  Location: Chr8:93810561-93969388 bp, + strand  Genetic Position: Chr8, 45.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:168245
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA stop codon was inserted at cysteine position 255 in a duplicated exon 7.2 using a "hit and run" targeting strategy. The absence of protein product in brain and pancreatic islets was confirmed immunologically. (J:168245)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:  4 strains or lines available
Original:  J:168245 Wang Y, et al., Augmented glucose-induced insulin release in mice lacking Go2, but not Go1 or Gi proteins. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1693-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory