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Gnao1tm2Lbi
Targeted Allele Detail
Nomenclature
Symbol: Gnao1tm2Lbi
Name: guanine nucleotide binding protein, alpha O; targetged mutation 2, Lutz Birnbaumer
MGI ID: MGI:4889046
Synonyms: Go1alpha-
Gene: Gnao1  Location: Chr8:93810561-93969388 bp, + strand  Genetic Position: Chr8, 45.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168245
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn IRES-beta galactosidase and PGK-neomycin cassette was inserted in exon 7.1 at the aspartic acid position 262. Isoform Go1-alpha was disrupted while beta galactosidase was placed under the control of the Gnao1 promoter. Absence of the protein product from brain and pancreatic islets was confirmed immunologically. (J:168245)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:  4 strains or lines available
References
Original:  J:168245 Wang Y, et al., Augmented glucose-induced insulin release in mice lacking Go2, but not Go1 or Gi proteins. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1693-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory