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Targeted Allele Detail
Symbol: Faim2tm1.1Jbsc
Name: Fas apoptotic inhibitory molecule 2; targeted mutation 1.1, Joerg B Schulz
MGI ID: MGI:4888719
Gene: Faim2  Location: Chr15:99497012-99528165 bp, - strand  Genetic Position: Chr15, 56.13 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:167848
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT flanked neomycin resistance cassette was inserted upstream of exon3 and exons 3 to 5 were flanked by loxP sites. The floxed exons were subsequently excised by crossing to Tg(EIIa-cre)C5379Lmgd mice. Absence of transcript was confirmed by RT-PCR and Northern blot analysis. Absence of full length protein was shown by Western blot analysis. (J:167848)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Faim2 Mutation:  4 strains or lines available
Original:  J:167848 Reich A, et al., Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia. J Neurosci. 2011 Jan 5;31(1):225-33
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory