Faim2^tm1.1Jbsc
Targeted Allele Detail

Summary

• Symbol: Faim2^tm1.1Jbsc
• Name: Fas apoptotic inhibitory molecule 2; targeted mutation 1.1, Joerg B Schulz
• MGI ID: MGI:4888719
• Gene: Faim2 Location: Chr15:99394893-99426046 bp, - strand Genetic Position: Chr15, 56.13 cM, cytoband F3
• Alliance: Faim2^tm1.1Jbsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167848
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neomycin resistance cassette was inserted upstream of exon3 and exons 3 to 5 were flanked by loxP sites. The floxed exons were subsequently excised by crossing to Tg(EIIa-cre)C5379Lmgd mice. Absence of transcript was confirmed by RT-PCR and Northern blot analysis. Absence of full length protein was shown by Western blot analysis. (J:167848)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Faim2 Mutation: 22 strains or lines available

References

• Original: J:167848 Reich A, et al., Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia. J Neurosci. 2011 Jan 5;31(1):225-33
• All: 4 reference(s)