Sfn^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Sfn^tm1Mak
• Name: stratifin; targeted mutation 1, Tak Mak
• MGI ID: MGI:4888527
• Gene: Sfn Location: Chr4:133327867-133329163 bp, - strand Genetic Position: Chr4, 66.25 cM, cytoband D3
• Alliance: Sfn^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168328
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into the coding exon. The absence of protein expression was confirmed by western blot analysis on intestinal epithelial cell extracts. (J:168328)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfn Mutation: 13 strains or lines available

References

• Original: J:168328 Su YW, et al., 14-3-3{sigma} regulates B-cell homeostasis through stabilization of FOXO1. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1555-60
• All: 1 reference(s)