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Hprt1tm6(VWF-lacZ)Aird
Targeted Allele Detail
Summary
Symbol: Hprt1tm6(VWF-lacZ)Aird
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 6, William C Aird
MGI ID: MGI:4888493
Synonyms: vWF2-Del1
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm6(VWF-lacZ)Aird page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168401
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA construct containing the human VWF promoter (-1143 to +1475) adjoined to lacZ was targeted to the Hprt locus. Expression of lacZ by the VWF promoter was confirmed by whole mount staining of mutant embryos and postnatal mice. (J:168401)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1272 strains or lines available
References
Original:  J:168401 Liu J, et al., Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle. Blood. 2011 Jan 6;117(1):342-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory