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Slco2a1tm1Vsch
Targeted Allele Detail
Summary
Symbol: Slco2a1tm1Vsch
Name: solute carrier organic anion transporter family, member 2a1; targeted mutation 1, Victor L Schuster
MGI ID: MGI:4888398
Synonyms: PGTNeo
Gene: Slco2a1  Location: Chr9:102885686-102973201 bp, + strand  Genetic Position: Chr9, 54.72 cM
Alliance: Slco2a1tm1Vsch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168442
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 1. The absence of protein expression was confirmed by immunohistochemistry. (J:168442)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slco2a1 Mutation:  36 strains or lines available
References
Original:  J:168442 Chang HY, et al., Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. Circulation. 2010 Feb 2;121(4):529-36
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory