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Igfbp3tm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Igfbp3tm1Lex
Name: insulin-like growth factor binding protein 3; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:4888286
Gene: Igfbp3  Location: Chr11:7206086-7213923 bp, - strand  Genetic Position: Chr11, 4.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168345
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a lacZ/neo cassette. The absence of circulating protein was confirmed by ELISA and immunoblotting. (J:168345)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igfbp3 Mutation:  7 strains or lines available
References
Original:  J:168345 Yamada PM, et al., Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology. 2010 Dec;151(12):5741-50
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory