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Targeted Allele Detail
Symbol: Aestm1.1Mmt
Name: amino-terminal enhancer of split; targeted mutation 1.1, Makoto M Taketo
MGI ID: MGI:4888012
Synonyms: Aesf
Gene: Aes  Location: Chr10:81559494-81566362 bp, + strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:168065
Parent Cell Line:  D3a2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 2 was flanked by two loxP sites, and after the first loxP site a PGK-Neo cassette flanked by FRT sequences was inserted into intron 1 immediately 5' to exon 2. The PGK-Neo selection sequence was removed by FLPe-mediated recombination. (J:168065)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aes Mutation:  8 strains or lines available
Original:  J:168065 Sonoshita M, et al., Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling. Cancer Cell. 2011 Jan 18;19(1):125-37
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory