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Ryr1tm2.1Alle
Targeted Allele Detail
Nomenclature
Symbol: Ryr1tm2.1Alle
Name: ryanodine receptor 1, skeletal muscle; targeted mutation 2.1, Paul D Allen
MGI ID: MGI:4887389
Synonyms: MH-RyR1-R163C, RyR1-R163C
Gene: Ryr1  Location: Chr7:29003340-29125151 bp, - strand  Genetic Position: Chr7, 16.94 cM, cytoband A2-B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168222
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ryr1 Mutation:  4 strains or lines available
References
Original:  J:168222 Yang T, et al., Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology. 2006 Dec;105(6):1164-75
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory