Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 37, TaconicArtemis |
MGI ID: |
MGI:4887237 |
Synonyms: |
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Taz,CAG-tetR)Bsf, Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte, ROSA26H1/tetO-shRNA:taz, TAZKD |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte page
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Defects of cardiac mitochondria and mitochondrion-associated membranes in Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte/Gt(ROSA)26Sor+ mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:167527
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Inducible, Knockdown) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte involves 1 genes/genome features (Tafazzin)
View all
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Mutation details: A short hairpin RNA directed against Taz was targeted into the Rosa26 locus. The shRNA sequence is under the regulation of the H1/tetO operator fusion promoter. Correct mRNA knock-down was confirmed in embryonic stem cells.
(J:167527)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:167527 Acehan D, et al., Cardiac and skeletal muscle defects in a mouse model of human barth syndrome. J Biol Chem. 2011 Jan 14;286(2):899-908 |
All: |
40 reference(s) |
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