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Targeted Allele Detail
Symbol: Birc3tm1Jda
Name: baculoviral IAP repeat-containing 3; targeted mutation 1, Jonathan D Ashwell
MGI ID: MGI:4887220
Synonyms: c-IAP2H570A
Gene: Birc3  Location: Chr9:7848700-7873187 bp, - strand  Genetic Position: Chr9, 2.46 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:166899
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 x C57BL/6
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 9 was replaced with one in which nucleotide substitutions result in the amino acid substitution of alanine for histidine at position 570 (H570A). A floxed neo cassette was inserted downstream of the modified exon 9. (J:166899)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Birc3 Mutation:  22 strains or lines available
Original:  J:166899 Conze DB, et al., Non-canonical NF-kappaB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2. PLoS Biol. 2010;8(10):e1000518
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory