Birc3^tm1Jda
Targeted Allele Detail

Summary

• Symbol: Birc3^tm1Jda
• Name: baculoviral IAP repeat-containing 3; targeted mutation 1, Jonathan D Ashwell
• MGI ID: MGI:4887220
• Synonyms: c-IAP2^H570A
• Gene: Birc3 Location: Chr9:7848700-7873187 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A2
• Alliance: Birc3^tm1Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 9 was replaced with one in which histidine cocon 572 (CAT) was changed to alanine (GCT) (p.H572A). A loxP site flanked neomycin resistance gene cassette was inserted downstream of the modified exon 9 (the last exon). (J:166899)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Birc3 Mutation: 31 strains or lines available

References

• Original: J:166899 Conze DB, et al., Non-canonical NF-kappaB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2. PLoS Biol. 2010;8(10):e1000518
• All: 5 reference(s)