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Fam3btm1Bkht
Targeted Allele Detail
Nomenclature
Symbol: Fam3btm1Bkht
Name: family with sequence similarity 3, member B; targeted mutation 1, Brant Burkhardt
MGI ID: MGI:4882127
Synonyms: PANDER-
Gene: Fam3b  Location: Chr16:97470965-97504936 bp, - strand  Genetic Position: Chr16, 57.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167823
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neomycin selection cassette in reverse orientation. This removed the transcriptional and translational start sites and the first 54 amino acids including the secretion signal peptide and helix A. mRNA was not detected in pancreatic islets, small intestine, liver, spleen, kidney, and brain by RT-PCR. Western blot analysis of pancratic islets demonstrated the absence of full length protein. (J:167823)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fam3b Mutation:  5 strains or lines available
References
Original:  J:167823 Robert-Cooperman CE, et al., Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function. Diabetes. 2010 Sep;59(9):2209-18
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory