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Targeted Allele Detail
Symbol: Mir146tm1.1Bal
Name: microRNA 146; targeted mutation 1.1, David Baltimore
MGI ID: MGI:4882045
Gene: Mir146  Location: Chr11:43374397-43374461 bp, - strand  Genetic Position: Chr11, 25.68 cM
Enlarged spleen and lymph nodes and multiorgan inflammation in Mir146tm1.1Bal/Mir146tm1.1Bal and Mir146tm2.1Bal/Mir146tm2.1Bal mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:167922
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe 295 bp of the pre-microRNA was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by qRT-PCR on bone marrow, spleen, and thymus extracts. (J:173671)
Generation of Mir146tm1.1Bal and Mir146tm2.1Bal alleles
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir146 Mutation:  4 strains or lines available
Original:  J:167922 Lu LF, et al., Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010 Sep 17;142(6):914-29
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory