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Nox4tm1.1Hwsc
Targeted Allele Detail
Nomenclature
Symbol: Nox4tm1.1Hwsc
Name: NADPH oxidase 4; targeted mutation 1.1, Harald H H W Schmidt
MGI ID: MGI:4881785
Gene: Nox4  Location: Chr7:87246096-87398710 bp, + strand  Genetic Position: Chr7, 48.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166948
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 14, and a neo cassette flanked by two loxP sites was inserted downstream of exon 15. The loxP-flanked regions, including exons 14 and 15 and the neo cassette, were removed by transient Cre-recombinase induced recombination. (J:166948)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nox4 Mutation:  24 strains or lines available
References
Original:  J:166948 Kleinschnitz C, et al., Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol. 2010;8(9)
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory