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Targeted Allele Detail
Symbol: Cnot3tm1Pngr
Name: CCR4-NOT transcription complex, subunit 3; targeted mutation 1, Josef M Penninger
MGI ID: MGI:4881781
Synonyms: not3-
Gene: Cnot3  Location: Chr7:3645268-3661109 bp, + strand  Genetic Position: Chr7, 2.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:167954
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2-9 were replaced with a PGK-neomycin selection cassette in reverse orientation. No mRNA was detected by RT-PCR in homozygous blastocysts nor was any protein detected by immunostaining. (J:167954)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnot3 Mutation:  17 strains or lines available
Original:  J:167954 Neely GG, et al., A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010 Apr 2;141(1):142-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory