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Phgdhtm1.2Shfu
Targeted Allele Detail
Nomenclature
Symbol: Phgdhtm1.2Shfu
Name: 3-phosphoglycerate dehydrogenase; targeted mutation 1.2, Shigeki Furuya
MGI ID: MGI:4881750
Synonyms: Phgdhflox
Gene: Phgdh  Location: Chr3:98313170-98339990 bp, - strand  Genetic Position: Chr3, 42.74 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167572
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 4, and an additional loxP site was inserted downstream of exon 5. The neo cassette, exon 4, and exon 5 were removed by cre-mediated recombination. Cre-mediated recombination removed the neo cassette leaving exon 4 and 5 floxed. (J:167572)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Phgdh Mutation:  4 strains or lines available
References
Original:  J:167572 Yang JH, et al., Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. J Biol Chem. 2010 Dec 31;285(53):41380-90
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory