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Daglbtm1.1Kano
Targeted Allele Detail
Nomenclature
Symbol: Daglbtm1.1Kano
Name: diacylglycerol lipase, beta; targeted mutation 1.1, Masanobu Kano
MGI ID: MGI:4881524
Synonyms: beta-KO, DGLbeta KO
Gene: Daglb  Location: Chr5:143464584-143505942 bp, + strand  Genetic Position: Chr5, 82.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167891
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette with a 5' loxP site was inserted upstream of exon 10, and an additional loxP site was inserted downstream of exon 11. Cre-mediated recombination removed the neo cassette and exons 10 and 11. The absence of transcript expression was coonfirmed by western blot analysis on forebrain and cerebellum extracts. (J:167891)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Daglb Mutation:  11 strains or lines available
References
Original:  J:167891 Tanimura A, et al., The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron. 2010 Feb 11;65(3):320-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory