Ago2^tm3Ghan
Targeted Allele Detail

Summary

• Symbol: Ago2^tm3Ghan
• Name: argonaute RISC catalytic subunit 2; targeted mutation 3, Greggory J Hannon
• MGI ID: MGI:4881451
• Synonyms: Ago2^ADH-NEO, Ago2^D597A-NEO
• Gene: Ago2 Location: Chr15:72967693-73056777 bp, - strand Genetic Position: Chr15, 33.92 cM
• Alliance: Ago2^tm3Ghan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161968
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Mice exhibit an A to C mutation that results in the amino acid substitution of alanine for aspartic acid at position 598 (D598A) within the catalytic DDH motif. (J:161968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ago2 Mutation: 54 strains or lines available

References

• Original: J:161968 Cheloufi S, et al., A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010 Jun 3;465(7298):584-9
• All: 2 reference(s)