Calb2^{tm2.1(cre/ERT2)Zjh}
Targeted Allele Detail

Summary

• Symbol: Calb2^{tm2.1(cre/ERT2)Zjh}
• Name: calbindin 2; targeted mutation 2.1, Z Josh Huang
• MGI ID: MGI:4880758
• Synonyms: Calb2-CreER-KI , Calb2-CreERT2-KI, Calb2-CreERT2-KI, Calretinin-CreER-KI, CR-CreER-KI, CR-CreERT2-KI
• Gene: Calb2 Location: Chr8:110869158-110894844 bp, - strand Genetic Position: Chr8, 57.44 cM
• Alliance: Calb2^{tm2.1(cre/ERT2)Zjh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6
• Project Collection: Neuroscience Blueprint cre

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Calb2^{tm2.1(cre/ERT2)Zjh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Calb2 (MGI:101914)

• Mutation details: A targeting vector was designed to insert a CreERT2 fusion gene, an SV40 polyA signal, and anFRT-flanked neo cassette into the initiation codon of the Calb2 (calbindin 2; also called calretinin or CR) locus. This construct was electroporated into C57BL/6-derived embryonic stem (ES) cells. Mutant mice were bred with Actin-FLPe mice to remove the neo cassette, (J:151755)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Calb2 (mouse) Summary of all recombinase alleles driven by Calb2. Comparative matrix view of recombinase activities Alliance mouse Calb2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Calb2 Mutation: 23 strains or lines available

References

• Original: J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009
• All: 9 reference(s)