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Targeted Allele Detail
Symbol: Klrd1tm1.1Lll
Name: killer cell lectin-like receptor, subfamily D, member 1; targeted mutation 1.1, Lewis L Lanier
MGI ID: MGI:4880661
Gene: Klrd1  Location: Chr6:129591782-129598775 bp, + strand  Genetic Position: Chr6, 63.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:167730
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette replaced part of exon 3 and all of exon 4. Cre-mediated recombination removed the neo cassette. The absence of the receptor heterodimers as confirmed by splenocyte labelling and sorting. (J:167730)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Klrd1 Mutation:  10 strains or lines available
Original:  J:167730 Orr MT, et al., Development and function of CD94-deficient natural killer cells. PLoS One. 2010;5(12):e15184
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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