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Pld2tm1.1Gdp
Targeted Allele Detail
Nomenclature
Symbol: Pld2tm1.1Gdp
Name: phospholipase D2; targeted mutation 1.1, Gilbert Di Paolo
MGI ID: MGI:4880012
Gene: Pld2  Location: Chr11:70540064-70558110 bp, + strand  Genetic Position: Chr11, 42.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166741
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6 x 129/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 13, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 15. This allele is created by using either Cre-mediated recombination to remove exons 13-15 and the selection cassette or Flp-mediated recombination to remove the FRT-flanked neo cassette, followed by Cre-mediated recombination to remove exons 13 to 15. The reduction in protein expression was confirmed by western blot analysis. (J:166741)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pld2 Mutation:  18 strains or lines available
References
Original:  J:166741 Oliveira TG, et al., Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci. 2010 Dec 8;30(49):16419-28
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory