Dlk1^tm1.1Jvs
Targeted Allele Detail

Summary

• Symbol: Dlk1^tm1.1Jvs
• Name: delta like non-canonical Notch ligand 1; targeted mutation 1.1, Jennifer V Schmidt
• MGI ID: MGI:4879107
• Synonyms: Dlk1^flox
• Gene: Dlk1 Location: Chr12:109418749-109429262 bp, + strand Genetic Position: Chr12, 60.17 cM, cytoband E-F1
• Alliance: Dlk1^tm1.1Jvs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167124
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and a neo cassette flanked by two loxP sites were inserted to flank the last two exons (5 and 6). The neo cassette was removed in vivo by Cre-mediated recombination. (J:167124, J:194130)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlk1 Mutation: 34 strains or lines available

References

• Original: J:167124 Waddell JN, et al., Dlk1 is necessary for proper skeletal muscle development and regeneration. PLoS One. 2010;5(11):e15055
• All: 9 reference(s)