Adgrg6^tm1Apr
Targeted Allele Detail

Summary

• Symbol: Adgrg6^tm1Apr
• Name: adhesion G protein-coupled receptor G6; targeted mutation 1, Andreas P Russ
• MGI ID: MGI:4878918
• Synonyms: GPR126^LacZ
• Gene: Adgrg6 Location: Chr10:14278327-14421403 bp, - strand Genetic Position: Chr10, 5.43 cM
• Alliance: Adgrg6^tm1Apr page

Heart abnormalities in Adgrg6^tm1Apr/Adgrg6^tm1Apr mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167309
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 18 was replaced with an IRES-lacZ-neo cassette via homologous recombination. PCR analysis confirmed the absence of wild-type transcript in homozygous mice. (J:167309)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrg6 Mutation: 63 strains or lines available

References

• Original: J:167309 Waller-Evans H, et al., The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010;5(11):e14047
• All: 1 reference(s)