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Ftotm1.1Pzg
Targeted Allele Detail
Nomenclature
Symbol: Ftotm1.1Pzg
Name: fat mass and obesity associated; targeted mutation 1.1, Pumin Zhang
MGI ID: MGI:4868738
Synonyms: Ftoflox
Gene: Fto  Location: Chr8:91313525-91668439 bp, + strand  Genetic Position: Chr8, 44.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166984
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3, and an FRT-flanked neo cassette with a 5' loxP site was inserted dowstream of exon 3. Flp-mediated recombination removed the neo cassette leaving exon 3 floxed. (J:166984)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fto Mutation:  28 strains or lines available
References
Original:  J:166984 Gao X, et al., The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One. 2010;5(11):e14005
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory