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Ahnaktm1Ysb
Targeted Allele Detail
Nomenclature
Symbol: Ahnaktm1Ysb
Name: AHNAK nucleoprotein (desmoyokin); targeted mutation 1, Yun Soo Bae
MGI ID: MGI:4868713
Gene: Ahnak  Location: Chr19:8989284-9076914 bp, + strand  Genetic Position: Chr19, 6.04 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167668
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details502 bp of the promoter and translational start codon were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:167668)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ahnak Mutation:  59 strains or lines available
References
Original:  J:167668 Lee IH, et al., Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex. J Biol Chem. 2008 Mar 7;283(10):6312-20
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory