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Targeted Allele Detail
Symbol: Cflartm1.2Pope
Name: CASP8 and FADD-like apoptosis regulator; targetred mutation 1.2, Richard M Pope
MGI ID: MGI:4868693
Synonyms: Flipd
Gene: Cflar  Location: Chr1:58711508-58758884 bp, + strand  Genetic Position: Chr1, 29.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:167430
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted just upstream of exon 2 (containing the ATG start codon). A floxed neomycin resistance cassette was also inserted in intron 3. The resistance cassette was removed prior to blastocyst injection, presumably by transient cre excision. This left exons 2 and 3 flanked by loxP sites. Miced with this floxed allele were then crossed to mice carrying a Zp3-cre transgene to produce the deleted allele. (J:167430)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cflar Mutation:  4 strains or lines available
Original:  J:167430 Huang QQ, et al., FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood. 2010 Dec 2;116(23):4968-77
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory