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Targeted Allele Detail
Symbol: Mmp14tm1.1Khol
Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1.1, Kenn Holmbeck
MGI ID: MGI:4868413
Synonyms: MT1-MMPLoxP
Gene: Mmp14  Location: Chr14:54431612-54441265 bp, + strand  Genetic Position: Chr14, 27.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:167396
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of eoxn 5. Flp-mediated recombination removed the neo cassette leaving exons 2 through 5 floxed. (J:167396)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  10 strains or lines available
Original:  J:167396 Szabova L, et al., Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood. 2010 Dec 16;116(25):5752-61
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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