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Targeted Allele Detail
Symbol: Aiptm2Bra
Name: aryl-hydrocarbon receptor-interacting protein; targeted mutation 2, Christopher A Bradfield
MGI ID: MGI:4867827
Synonyms: Ara9fxneo
Gene: Aip  Location: Chr19:4164446-4175858 bp, - strand  Genetic Position: Chr19, 3.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:141575
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 6. Reduced protein expression was confirmed by western blot analysis on heart, liver, kidney, spleen, and thymus extracts. This allele is hypomorphic. (J:141575)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aip Mutation:  17 strains or lines available
Original:  J:141575 Lin BC, et al., Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem. 2007 Dec 7;282(49):35924-32
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory