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Gbatm1.2Pmis
Targeted Allele Detail
Nomenclature
Symbol: Gbatm1.2Pmis
Name: glucosidase, beta, acid; targeted mutation 1.2, Pramod K Mistry
MGI ID: MGI:4867660
Synonyms: GBA1KO
Gene: Gba  Location: Chr3:89202928-89208681 bp, + strand  Genetic Position: Chr3, 39.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167081
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
    Cre-mediated recombination removed exons 8 through 11. (J:167081)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gba Mutation:  10 strains or lines available
References
Original:  J:167081 Mistry PK, et al., Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19473-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory