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Transgene Detail
Symbol: Tg(CAG-ELN*)2Zu
Name: transgene insertion 2, Zsolt Urban
MGI ID: MGI:4867516
Synonyms: CL mice
Transgene: Tg(CAG-ELN*)2Zu  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(CAG-ELN*)2Zu expresses 1 gene
Mutation detailsA cytomegalovirus immediate-early enhancer and a chicken beta actin promoter drive the expression of a mutant human elastin cDNA, an internal ribosomal entry site (IRES) and an EGFP cDNA. The mutation in human elastin is based on the major mRNA isoform in a family with autosomal dominant cutix laxa caused by a 25 base pair deletion, 2114_2138del, located in exon 30 of the elastin gene. This frameshift mutation, which is frequently subject to removal by normally occurring alternative splicing, results in the replacement of the C-terminus of tropoelastin by a missense peptide sequence of 81 amino acids. (J:166809)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:166809 Hu Q, et al., Mechanisms of emphysema in autosomal dominant cutis laxa. Matrix Biol. 2010 Sep;29(7):621-8
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory