Tg(KRT5-rtTA)#Glk
Transgene Detail

Summary

• Symbol: Tg(KRT5-rtTA)#Glk
• Name: transgene insertion, Adam Glick
• MGI ID: MGI:4867436
• Synonyms: K5-tTA
• Transgene: Tg(KRT5-rtTA)#Glk Location: unknown
• Alliance: Tg(KRT5-rtTA)#Glk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: This transgene contains the reverse tetracycline-regulated transactivator gene rtTA under control of the bovine keratin 5 promoter. The rtTA coding sequence lies downstream of approximately 5.2 kilobases of DNA from the 5' flanking region of the keratin followed by a beta-globin intron and upstream of an SV40 polyadenylation signal. Eleven lines were generated. The pound symbol (#) is used to denote when no line is psecified or multiple lines are pooled. (J:65791)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:65791 Diamond I, et al., Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol. 2000 Nov;115(5):788-94
• All: 61 reference(s)