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Sirt6tm2.1Cxd
Targeted Allele Detail
Summary
Symbol: Sirt6tm2.1Cxd
Name: sirtuin 6; targeted mutation 2.1, Chu-Xia Deng
MGI ID: MGI:4867399
Synonyms: Sirt6neo
Gene: Sirt6  Location: Chr10:81457621-81463631 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance: Sirt6tm2.1Cxd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167023
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe loxP site inserted upstream of exon 2 was lost leaving a floxed neo cassette downstream of exon 3. The absence of protein expression was confirmed by western blot analysis. (J:167023)
Generation of the Sirt6tm2.1Cxd and Sirt6tm2.2Cxd alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt6 Mutation:  39 strains or lines available
References
Original:  J:167023 Xiao C, et al., SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 2010 Nov 19;285(47):36776-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory