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Targeted Allele Detail
Symbol: Hadhtm1Csta
Name: hydroxyacyl-Coenzyme A dehydrogenase; targeted mutation 1, Charles A Stanley
MGI ID: MGI:4867189
Synonyms: SCHAD ko
Gene: Hadh  Location: Chr3:131233419-131272101 bp, - strand  Genetic Position: Chr3, 60.86 cM
Abnormal distribution of alpha-cells throughout the islet in Hadhtm1Csta/Hadhtm1Csta mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:166803
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 1 was replaced by a neomycin resistance cassette. Protein and mRNA were not detected in any tissue tested. (J:166803)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hadh Mutation:  7 strains or lines available
Original:  J:166803 Li C, et al., Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 2010 Oct 8;285(41):31806-18
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory