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Targeted Allele Detail
Symbol: Abl1tm2.1Goff
Name: c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 2.1, Stephen P Goff
MGI ID: MGI:4850040
Synonyms: AblF
Gene: Abl1  Location: Chr2:31688376-31804227 bp, + strand  Genetic Position: Chr2, 21.86 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:166211
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted at the end of intron 4 and a neo cassette flanked by two loxP sites were inserted into the middle of intron 6. The neo cassette was deleted by transiently transfection of an expression vector of Cre recombinase in the ES cells. Two independent heterozygous ES cell clones. (J:166211)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abl1 Mutation:  56 strains or lines available
Original:  J:166211 Qiu Z, et al., Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci. 2010 Oct 27;30(43):14430-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory