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Tg(Spo11-cre)D5Mpel
Transgene Detail
Nomenclature
Symbol: Tg(Spo11-cre)D5Mpel
Name: transgene insertion D5, Manuela Pellegrini
MGI ID: MGI:4850038
Synonyms: Spo11Cre, Spo11-IRES-Cre
Transgene: Tg(Spo11-cre)D5Mpel  Location: unknown  
Transgene
origin
Strain of Origin:  BALB/c x C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe BAC RP23-20N4 containing the entire Spo11 locus (including 188kb of sequence upstream of the initiation codon and 57kb downstream of the stop codon) was engineered by homologous recombination to insert an IRES-cre-(Frt-flanked) neo fragment immediately downstream of the stop codon. The neo was subsequently removed by Flp in bacteria. The modified BAC was injected into the pronuclei of fertilized eggs. Two named lines, D5 and H9, were generated and studied further. (J:166888)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Spo11     Summary of all recombinase alleles driven by Spo11.
 

Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:166888 Pellegrini M, et al., Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase. J Cell Sci. 2011 Jan 1;124(Pt 1):91-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory