Cops5^tm1Fxc
Targeted Allele Detail

Summary

• Symbol: Cops5^tm1Fxc
• Name: COP9 signalosome subunit 5; targeted mutation 1, Francois-Xavier Claret
• MGI ID: MGI:4849637
• Gene: Cops5 Location: Chr1:10094825-10108384 bp, - strand Genetic Position: Chr1, 2.29 cM
• Alliance: Cops5^tm1Fxc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166561
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1, which contains the translation initiation site, was replaced with a neo cassette. (J:166561)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops5 Mutation: 23 strains or lines available

References

• Original: J:166561 Tian L, et al., Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010 Nov 18;29(46):6125-37
• All: 1 reference(s)