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Targeted Allele Detail
Symbol: Hprttm1(CAG-Sox9,-EGFP)Akis
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 1, Andreas Kispert
MGI ID: MGI:4849516
Synonyms: HprtSox9
Gene: Hprt  Location: ChrX:52988137-53021659 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Germline Transmission:  Earliest citation of germline transmission: J:166547
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Hprttm1(CAG-Sox9,-EGFP)Akis expresses 1 gene
Mutation detailsExon 1 was replaced with a CAG promoter, loxP site, neo and stop cassette, loxM site, and an inverted Sox9 cDNA followed by an IRES and EGFP. Cre-mediated recombination is required to achieve expression of Sox9 and EGFP. (J:166547)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  31 strains or lines available
Original:  J:166547 Airik R, et al., Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme. Hum Mol Genet. 2010 Dec 15;19(24):4918-29
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory